b, Summary of tests for non-additive effects in combined alleles compared to individual mutations in R1 and R4. Stacked bar charts and box plots show locule number quantifications (right). ![]() In alleles with combined mutations, original mutations in one region are labelled by superscript numbers while newly generated mutations in the other region are designated by superscript letters (Extended Data Fig. ![]() Schematic and heat map representations of alleles with mutations in R1 or R4 alone (top left), and of alleles with combined mutations in R1 and R4 from trans-targeting (middle left) or sequential editing (bottom left). ![]() Combining mutations in conserved cis-regulatory regions reveals additive, redundant and synergistic relationships between sequences in the SlCLV3 promoterĪ, Combinations of mutations in R1 and R4 show increased locule numbers compared to individual mutations in these regions.
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